THE EFFECT OF TOTAL BODY X IRRADIATION OF THE RABBIT ON THE REJECTION OF HOMOLOGOUS SKIN GRAFTS AND ON THE IMMUNE RESPONSE
Journal Article
·
· Journal of Immunology (U.S.)
OSTI ID:4829258
The effect of sublethal (400 r), midlethal (600 r), and near-lethal (1100 r) total-body irradiation on the ability of rabbits to reject homologous skin grafts, to develop delayed hypersensitivity, and to form circulating antibodies to bovine gamma -globulin (BGG) and sheep erythrocytes was studied. Different intervals were allowed to elapse between x irradiation and the presentation of antigens. Maximum prolongation of skin graft rejection time occurred with 400 r when grafting was done on the same day as irradiation. A 2- fold increase in the median rejection time was observed, and the occasional animal retained its graft for as long as 7 to 10 times the normal. No great advantage appears to be gained by increasing the radiation dose from 400 to 600 r and it is possible that prolongation of skin graft rejection time by irradiation can be as well obtained with a sublethal as with a midlethal dose. The time between irradiation and grafting appears to be as critical as the dose. The ability of the animal to develop delayed hypersensitivity to old tuberculin was greatly reduced when the antigen was given within hours of irradiation. Heavier doses of irradiation (600 and 1100 r) appear in many instances to permanently suppress the animal's ability to develop delayed hypersensitivity. There was a high degree of correlation between the time of rejection of skin grafts and the development of hemolysins; the shorter the skin graft rejection time, the higher the hemolysin titer. No correlation was obtained between skin graft rejection time and the anti-BGG titers. (H.H.D.)
- Research Organization:
- Harvard Univ., Boston
- NSA Number:
- NSA-16-020276
- OSTI ID:
- 4829258
- Journal Information:
- Journal of Immunology (U.S.), Journal Name: Journal of Immunology (U.S.) Vol. Vol: 88; ISSN JOIMA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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