THE ROLE OF HUMORAL ANTIBODIES IN REJECTION OF SKIN HOMOGRAFTS IN RABBITS. II. PASSIVE TRANSFER OF TRANSPLANTATION IMMUNITY BY SENSITIZED LYMPH NODE CELLS WITHIN DIFFUSION CHAMBERS
Transplantation immunity was successfully transferred to rabbits by sensitized lymphoid cells enclosed in Millipore chambers in x-irradiated and nonirradiated recipients. The chambers allowed antibody to diffuse from the cells contained therein. In nonirradiated rabbits graft rejection time was reduced by 2.8 days, Irradiation of rabbits with 400 or 800 r significantly reduced the rejection time. A dose of 400 r whole-body radiation in rabbits depressed only the immune response mediated by humoral antibodies, while the delayed form of hypersensitivity to the same antigen remained unaltered. On the other hand, 800 r depressed both forms of the immune response. The data suggest that the effect of radiation on skin homografts in the rabbit is due to the suppression of humoral antibodies, since doubling the dose of x rays with the consequent blocking of deiayed hypersensitivity had no further influence on the average time of homograft survival. The fact that passive transfer of transplantation immunity, by means of sensitized lymphoid cells enclosed within diffusion chambers, was accomplished in nonradiated and radiated rabbits indicates that humoral antibodies play an important role in rejection of siun homografts in the rabbit. (H.H.D.)
- Research Organization:
- Univ. Nacional Autonoma de Mexico, Mexico City
- NSA Number:
- NSA-17-010425
- OSTI ID:
- 4711983
- Journal Information:
- J. Exptl. Med., Vol. Vol: 116; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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