Immunizing Effect of Irradiated Cercariæ of Schistosoma Mansoni in Rhesus Monkeys
Hamsters were used for estimating the dose of x irradiation which was necessary to prevent cercariae of S. mansoni from developing to maturity but which still allowed them to migrate through the lungs and reach the liver. An x- ray dose of 3000 r prevented any cercariae from surviving for > 6 weeks in hamsters; 2000 r prevented all but 1% of the worms from surviving beyond this time. Attempts to protect rhesus monkeys against subsequent challenge with S. mansoni were made by exposing them to cercariae irradiated at 2000 and 3000 r. The protection was found to be incomplete.
- Research Organization:
- National Inst. for Medical Research, London
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-020202
- OSTI ID:
- 4829238
- Journal Information:
- Nature (London), Journal Name: Nature (London) Journal Issue: 4834 Vol. 194; ISSN 0028-0836
- Publisher:
- Nature Publishing Group
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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