THE EFFECT OF X RAYS ON ANAPHYLAXIS IN THE GUINEA PIG
Guinea pigs were irradiated with a total-body dose of 200 r 7 days before active sensitization by a single intracutaneous dose of 5 mg ovalbumin. Over 50% of these animals survived a challenging dose of antigen 25 days later, whereas all of the nonirradiated animals died in acute anaphylactic shock within 3-4 min. When the same amount of radiation was given in fractional doses (10 r daily for 20 days), 30--40% of the animals survived anaphylactic shock. In guinea pigs passively sensitized by intracardiac injection of antiovalbumin, irradiation had no appreciable protective effect. Ileum isolated from these passively sensitized animals responded to the presence of antigen even after irradiation of the animals with 10,000 r. Irradiation of rabbit antiovalbumin immune serum with 10,000, 50,000, or 100,000 r failed to prevent its ability to elicit anaphylaxis and did nor reduce its precipitin titer. In fact, irradiation of the antiserum increased the amount of precipitate it formed with antigen. The results confirm that radiation does not impair the reactivity of antibody and that it inhibits anaphylaxis by blocking antibody synthesis. (H.H.D.)
- Research Organization:
- Medical Univ., Debrecen, Hungary
- NSA Number:
- NSA-16-020252
- OSTI ID:
- 4829236
- Journal Information:
- Acta Physiologica Academiae Scientiarum Hungaricae (Hungary), Vol. Vol: 20; Other Information: Orig. Receipt Date: 31-DEC-62
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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