INFLUENCE OF X-RAY IRRADIATION UPON THE METABOLISM OF PORPHYRIN BODIES. I. THE QUANTITY OF PORPHYRIN BODIES IN THE TISSUES

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)

OSTI ID:4828695

Sugihara, T

Whole-body x irradiation (from 50 to 600 r) was performed in guinea pigs. Generally, porphyrin bodies, especially metalloporphyrin, decreased in the tissues. ln the liver and spleen the decreases were distinct within 30 min aiter irradiation with 400 or 600 r, the mininmum value being ca. 1/3-1/4 of the normal value. In the lung, heart, intestine, muscle, and kidney the decreases were slight. The adrenal gland showed no change. Blood porphyrin decreased. The changes in other tissue porphyrins werc slight. Porphyrin bodies in the urine showed an increase though this was not as distinct as the change in the tissues. The degree of changes was related to the irradiation dose, and it was nwore considerable after a single irradiation than with the fractionated technique. The changes could be ascribed to disturbance oi the tissue function by x irradiation. (Abstr. Japan Med., 1: No. l3, 1961)

• Research Organization: Kyoto Univ.
• NSA Number: NSA-16-004082
• OSTI ID: 4828695
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 20; ISSN NHGZA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
GUINEA PIGS
HEART
HETEROCYCLICS
INTESTINE
KIDNEYS
LIVER
LUNGS
MUSCLES
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
PYRROLES
RADIATION DOSES
RADIATION EFFECTS
SPLEEN
X RADIATION