ELECTRON MICROSCOPIC OBSERVATIONS ON PRIMARY AND SERIALLY PASSAGED RADIATION-INDUCED MYELOID LEUKEMIAS OF THE RF MOUSE

Journal Article · Sun Jul 01 04:00:00 EDT 1962 · Cancer Research

OSTI ID:4828422

Parsons, D F; Upton, A C; Bender, M A; Jenkins, V K; Nelson, E S; Johnson, R R

RF mice with primary and passaged radiation-induced myeloid leukemia were examined with the electron microscope for the presence of virus particles. The spleen, liver, and bone marrow of nearly all such mice exarnined contained small numbers of these particles. In one of two animals in which other tissues (thymus, pancreas, salivary glands, lymph nodes, omentum, lung, and brain) were examined, the thymus and pancreas also showed small numbers of particles. Much larger numbers of particles of the same morphology were seen in tissue cultures derived from the serially passaged leukemias. One control tissue culture, but none of the control tissues, contained similar particles. The particles resembled those associated with AKR mouse lymphoid leukemia (Type C in Bernhard's morphological classification of tumor viruses). Although cell-free filtrates of the particle-containing tissues have shown lymphoid and myeloid leukemogenic activity, the possible etiologic significance of the particles remains to be established. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• NSA Number: NSA-16-025199
• OSTI ID: 4828422
• Journal Information: Cancer Research, Journal Name: Cancer Research Vol. Vol: 22
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BONE MARROW
BRAIN
ELECTRON MICROSCOPY
GLANDS
LEUKEMIA
LIVER
LUNGS
LYMPH NODES
LYMPH SYSTEM
MICE
MOMENTUM
PANCREAS
SALIVARY GLANDS
SPLEEN
THYMUS
VIRUSES