Increased Survival from Radiation by Mixtures of Radioprotective Compounds
>Serotonin, MEA ( BETA -mercaptoethylamine), and Aet (S, BETA aminoethylisothiuronium) are effective protectors against ionizing radiation; 10 mu M serotonin, 20 mu M AET, or 30 mu M MEA, when given alone to mice prior to exposure of lethal dose of 800 r, offered 50 to 65 per cent protection. At 1,100 r, no protection by any of these agents was found. However, when nilxtures of the above agents (5 mu M serotonin plus l0 mu M AET or 5 mu M serotonin plus 30 mu M MEA) were administered, 100 per cent and 70 to 80 per cent protection were obtained in mice exposed to 800 r and 1,100 r, respectively. (auth)
- Research Organization:
- Army Medical Research Lab., Fort Knox, Ky.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-021990
- OSTI ID:
- 4827720
- Journal Information:
- Acta Radiologica, Journal Name: Acta Radiologica Journal Issue: 2 Vol. 58; ISSN 0001-6926
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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