EXPERIMENTAL STUDIES ON THE EFFECTS OF AN INTRAVENOUSLY ADMINISTERED RADIOISOTOPE UPON THE FOETUS

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)

OSTI ID:4825381

Noma, E

P/sup 32/ was given in a dosage of l.2 mu c/g to 5 mice in the latter period of pregnancy, and its intrabodily distribution in mice and fetuses was investigated at 2.5 hours after injection. Further P/sup 32/ was given in dosages of 2.4, l.2, 0.5, and 0.3 mu c/g, respectively, to 50 mice in the middle and latter period of pregnancy, and their 249 baby mice were morphologically examined periodically after birth. The intrabodily distribution in pregnant mice was similar to that in non-pregnant mice. When P/sup 32/ was given in dosages of l.2 mu c/g, an average of 0.32 mu c went through the placenta into each fetus. Damage caused in the infant mouse by the administration of P/sup 32/ to the parent mouse chiefly consisted of primary changes due to the uptake of P/sup 32/ by the former. A dosage of 2.4 mu c/g reduced the number of offspring. Growth impediment was noted in the offspring of a mouse to which P/sup 32/ was given in a dosage of over l.2 mu c/g during pregnancy. The administration of P/sup 32/ during the middle period of pregnancy produced more marked growth impediment than when given during the latter period. The gonads of the fetus displayed a very high radiosensitivity and so underwent marked degeneration when P3/ was given to the parent mouse in a dosage exceeding l.2 mu c/g. With the administration of less than 0.6 mu c/g, the infant mice were able to achieve nearly normal pregnancy ending in delivery at full term. With the administration of over 1.2 mu c/g, however, the first filial generation did not have parturition till l6 weeks after birth. The maximal dose for the pregnant mouse which did not producc histological changes in the gonads of the baby mouse was 0.3 mu c/g for the testis and 0.6 mu c/g for the ovary. (Abstr. Japan Mied., 1: No. 13, l961)

• Research Organization: Kobe Medical Coll., Japan
• NSA Number: NSA-16-004081
• OSTI ID: 4825381
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 20; ISSN NHGZA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
FETUSES
GONADS
METABOLISM
MICE
PHOSPHORUS 32
PREGNANCY
QUANTITY RATIO
RADIATION INJURIES