Attempt to assess the inheritable effect of methylmercury toxicity subsequent to prenatal exposure of mice

Journal Article · Sat Oct 01 04:00:00 EDT 1988 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF02020994· OSTI ID:6396181

Inouye, M; Kajiwara, Y

In a previous experiment, the authors treated pregnant mice with 20 mg/kg methylmercuric chloride and observed the growth of their offspring. After the termination of the experiment, three male offspring were mated with ten untreated females. Four fetuses with neural tube defects and two with minor malformations were found among 73 offspring when examined at term. Although it was hoped that this high percentage of malformations might be just a change occurrence, they decided to examine the effect of maternal exposure to methylmercury on the reproduction of the second filial generation (F2). Since many offspring died during the perinatal period in the previous experiment when pregnant mice were treated with 20 mg/kg methylmercuric chloride, dams were given 15 mg/kg of the chemical to obtain a viable first filial generation (F1) in the present experiment. The F1 males were used to determine the potential of methylmercury to produce male-mediated fetal effects, and female littermates were examined for mercury retention.

• Research Organization: National Institute for Minamata Disease, Kumamoto (Japan)
• OSTI ID: 6396181
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 41:4; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
CHLORIDES
CHLORINE COMPOUNDS
CONGENITAL MALFORMATIONS
DISEASES
GENETIC EFFECTS
HALIDES
HALOGEN COMPOUNDS
HEREDITARY DISEASES
MALFORMATIONS
MAMMALS
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
METHYLMERCURY
MICE
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PATHOLOGICAL CHANGES
PRENATAL EXPOSURE
RODENTS
TOXICITY
VERTEBRATES