TREATMENT AND PROPHYLAXIS OF RADIATION DAMAGE
Journal Article
·
· American Journal of Pharmacy and the Sciences Supporting Public Health (U.S.) Changed to PM, Pharm. Manage.
OSTI ID:4823685
Exposure to ionizing radiation manifests itself in different types of injuries depending upon the dose, tissue area irradiated, duration of exposure, and intensity and wave length of the source. The biological effects of ionizing radiation lead to an alteration of tissue constituents, either directly by interaction with target molecules or indirectly by formation of active, free radicals from tissue water molecules. The protective agents which have proven most effective against radiation inlury are those that possess a sulfhydryl group. Reaction mechanisms involved in the protective effects of mercaptoalkylamines, mercaptoguanidines, thiozolidines and aminoalkylthiosulfuric acid, dithiocarbamates, sulfoxides, mercaptopyridoxine and BAL derivatives, and miscellaneous S-containing protective compounds are discussed. The effects of anoxia, chelating agents, and other radioprotective agents are reviewed briefly. Agents or procedures that offer some effectiveness against post-radiation injury include blood and bone marrow transfusions, antibiotic therapy, and the administration of antihemorrhogic agents. Significant progress has been made in protection against radiation injuries, but many of the agents presently being tested are still too toxic for extensive human use at high radiation dose levels. (37 references) (C.H.)
- Research Organization:
- Philadelphia Coll. of Pharmacy and Science, Philadelphia
- NSA Number:
- NSA-16-000077
- OSTI ID:
- 4823685
- Journal Information:
- American Journal of Pharmacy and the Sciences Supporting Public Health (U.S.) Changed to PM, Pharm. Manage., Journal Name: American Journal of Pharmacy and the Sciences Supporting Public Health (U.S.) Changed to PM, Pharm. Manage. Vol. Vol: 133; ISSN AJPRA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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