The Small Intestine in Acute Radiation Death in the Dog
Survival time and changes in venous hematocrit and rectal temperature were measured in anesthetized, eventrated dogs after 3000 r of x irradiation under the following conditions of exposure: normal unoperated total- bodyirradiated controls; eventrated total-body-irradiated controls; body- protected, gut-irradiated eventrated group. and body-irradiated, gut-protected eventrated group. Both partially protected groups survived significantly longer than the normal control group and the eventrated control group, the body protected, gut-irradiated eventrated group relatively longer than the other three. The eventrated controls survived as long as the unoperated normal controls. Weight loss and hemoconcentration were less in the gutprotected animals. It is suggested that there is less fluid loss in this group owing to the protection of the gut. Histopathologic study of the intestine (jejunum and ileum) suggests that at death there may be some sparing of crypts in dogs with the intestine irradiated. In one case, major recovery occurred in an animal that survived 112 days. There is also evidence that shielding of the intestine was not 100% effective in all cases. It is concluded that exposure of the intestine alone to a supralethal dose of x radiation is not tantamount to total-body irradiation. The validity of considering intestinal radiation death a true modality is discussed.
- Research Organization:
- National Naval Medical Center, Bethesda, Md.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-005225
- OSTI ID:
- 4822670
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 6 Vol. 15; ISSN 0033-7587
- Publisher:
- Radiation Research Society
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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