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EFFECT ON CIRCULATING BLOOD VOLUME OF PARTIAL SHIELDING OF RAT INTESTINE DURING X-IRRADIATION

Journal Article · · Radiation Research
DOI:https://doi.org/10.2307/3570444· OSTI ID:4345533
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A lethal acute intestinal radiation syndrome was produced in rats by 100 r of x irradiation. All animals were exposed with head and thoracic regions leadshielded in order to minimize hematopoietic damage. By using the P/sup 32/- tagged red cell dilution method, circulating blood volume changes were studied in groups of animals that had been exposed with or without additional lead-shielding of a very short segment of ileum, a procedure which decreases intestinal radiation mortality significantly. Total circulating blood volume decreased markedly in both groups after irradiation, but the loss was significantly less severe in rats exposed with the ileal segment shielded. Four days after irradiation, blood volumes averaged 63 and 78% of normal in control irradiated and ileal segment-shielded groups, respectively. Although both groups sustained some loss of red cells, the total blood volume losses measured were mainly due to loss of plasma, presumably reflecting fluid loss by way of the intestinal lumen. Plasma volumes averaged 40 and 66% of normal on the fourth day in control and ileal segment-shielded groups, respectively. Rats surviving the critical period for intestinal radiation deaths showed blood volumes approaching normal levels on the sixth day. With the hematocrit taken as an approximate index of plasma volume change, serial determinations made on individual animals of both groups showed that mortality and survival time were closely related to the degree and rate of plasma loss. (auth)
Research Organization:
U.S. Naval Radiological Defense Lab., San Francisco
Sponsoring Organization:
USDOE
NSA Number:
NSA-12-009612
OSTI ID:
4345533
Journal Information:
Radiation Research, Journal Name: Radiation Research Vol. Vol: 8
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BLOOD FORMATION
BLOOD PLASMA
BRAIN
ERYTHROCYTES
INTESTINE
LEAD
LETHAL DOSE
LUNGS
PHOSPHORUS 32
RADIATION INJURIES
RADIATION SICKNESS
RATS
SHIELDING
TRACER TECHNIQUES
X RADIATION