Modification of Intestinal Radiation Death by Surgical Means
A dose of x irradiation which was a LD100 about 8 days was given to at least 50% of the exteriorized ileum and jejunum of young adult male Holtzman rats. In some, this was the only treatment; in others, the irradiated segment was made into a Thiry or Thiry-Vella fistula 2 days postirradiation. This procedure extended the survival time an average of 4 days beyond that of irradiated controls; some animals lived 14 days longer. Establishing a fistula with the irradiated segment did not modify histological damage bat did apparently reduce the bloody diarrhea and water loss via rectum ordinarily seen in irradiated controls. The significance of these findings and their compatibility with current theories of causes of intestinal radiation death is discussed. Although the postirradiation resection or conversion into a fistula of the irradiated exteriorized intestine did prolong survival time when compared to irradiated controls with the gut left in place, resection was not of value when done prior to whole-body irradiation or after abdomen exposure, since survival times were as usual (about 3 1/2 days). The results show that it is possible to produce 3- to 5-day death in rats with an exposure dose as low as 1500 r, even though the in fluence of the major portion of the small intestine is absent. This is in contrast to the response of the mouse where at least 50% of the jejunum and ileum must be irradiated to produce intestinal death.
- Research Organization:
- Univ. of Iowa, Iowa City
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-021977
- OSTI ID:
- 4815271
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 1 Vol. 17; ISSN 0033-7587
- Publisher:
- Radiation Research Society
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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