THE EFFECT OF WHOLE BODY X-IRRADIATION ON BLOOD PRESSURE IN THE RAT

Technical Report · Tue May 01 04:00:00 EDT 1962

OSTI ID:4818520

Phillips, R D; Kimeldorf, D J

Blood pressure was measured at a peripheral and central site in the rat. Pressure at the peripheral site was determined by a tail occlusion cuff method, while central pressure was measured by aortic intubation. There was marked decrease in blood pressure measured at the peripheral site 8 hr after the anlmals were exposed to 485 rads of x rays, with a return to control values by 3 days after exposure. Aortic blood pressure, however, was not altered at this dose level. There was a mild decrease in aortic pressure 24 and 48 hr after 970 rads and marked hynotension 8 and 24 hr following 1940 rads. The aortic blood pressure response to various stimuli was also altered after 970 rads, but not after 485 rads of x rays. These data demonstrate that blood pressure at a peripheral site can be decreased at a dose level which does not affect central pressure. It is suggested that this differential effect in blood pressure is a result of a radiation response in peripheral circulation. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-16-018769
• OSTI ID: 4818520
• Report Number(s): USNRDL-TR-562
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AORTA
BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BLOOD PRESSURE
BLOOD VESSELS
BODY
RADIATION DOSES
RADIATION EFFECTS
RATS
X RADIATION