THE INITIAL LEUCOCYTOSIS AND ITS POSSIBLE MECHANISM IN RABBITS AFTER A SINGLE AND WHOLE BODY $gamma$-IRRADIATION

Journal Article · Sun Mar 01 04:00:00 EST 1964 · Sci. Sinica (Peking)

OSTI ID:4017762

Ma, S; Wu, C

Twenty-eight male sex-matured rabbits, each weighing 2 to 3 kg, were used for the study of the effects of single and whole body gamma -irradiations of 100 r, 300 r, 500 r, 800 r, and 1000 r on the leucocyte levels of the peripheral and the central blood and on the quantitative changes of the cells of the heterophil series in bone marrow. No significant differences in the numbers of leucocytes of the peripheral and the central blood were found in animals before irradiation and in the non-irradiated ones. Significant increase in the number of leucocytes in the peripheral blood (being 51 to 82% greater) was observed in all groups 7 hr after irradiation, whereas in the central blood, the number of leucocytes decreased or maintained at the pre-irradiation levels with the exception of the 1000 r group which showed an increase but was still 48% less as compared with its corresponding peripheral blood. Hfence, significant difference in the leucocyte levels of the peripheral and the central blood was found 7 hr after irradiation in all irradiated groups. In the lower dose groups (100 r, 300 r, and 500 r), the leucocyte levels of the peripheral and the central blood 24 hr after irradiation fell below the pre-irradiation levels and approached one another very closely, whereas in the higher dose groups (800 r and 1000 r) only that of the central blood decreased and the peripheral blood was still in a state of leucocytosis. Hence, in the higher dose group, significant difference in the leucocyte levels of the two kinds of blood 24 hr after irradiation still persisted as in the case of 7 hr after irradiation. The difference in the number of leucocytes in the peripheral and the central blood during the period of the initial leucocytosis is probably brought about by the migration of a great number of leucocytes from the large blood vessels into the small ones (such as arterioles, venules, and capillaries) and through the walls of capillaries) leucocytes moved towards the injured tissues. Leucocytosis does not occur in the whole blood circulation and, in most cases, it only appears in the peripheral blood. The decrease in the number of leucocytes in the central blood concomitartly with the leucocytosis of the peripheral one suggests the possibtlity that it is the redistribution of leucocytes in blood vessels of different diameters rather than the accelerative discharges of the heterophils from the marrow that plays an important role in the initiation of leucocytosis, (auth)

• Research Organization: Inst. of Biophysics, Academia Sinica, Peking
• NSA Number: NSA-18-019697
• OSTI ID: 4017762
• Journal Information: Sci. Sinica (Peking), Journal Name: Sci. Sinica (Peking) Vol. Vol: 13
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BLOOD CELLS
BODY
BONE MARROW
GAMMA RADIATION
IRRADIATION
LEUCOCYTES
PHYSIOLOGY
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
STANDARDS
VARIATIONS