THE RADIOPROTECTIVE EFFECT OF MIXTURES OF AET AND SEROTONIN
Technical Report
·
OSTI ID:4811494
Experiments were conducted to determine the protection provided the erythropoietic system of rats against wholebody, gamma radiatton by mixtures of AET (2-arninoethylisothiouronium bromide) and serotonin (5-hydroxytryptamine). The incorporation of Fe/sup 59/ into newly formed red blood cells was used as the criterion of the radioprotection afforded. Two concentrations of AET plus serotonin (40 mu M AET, 20 mu M serotonin and 20 mu M AET, 10 mu M serotonin) offered initial protection against the depression of the erythropoietic rate associated with radiation exposure. The higher concentration of this mixture produced mortality due to the toxicity of the compounds. AET and serotonin mixtures did not alter the initial radiation-induced leucopenia. However, the protected rats had higher white blood cell counts l8 days after radiation exposure. Daily gains in body weight appeared somewhat greater in the rats injected with AET and serotonin than in the nonprotected, irradiated animals. (auth)
- Research Organization:
- Aeronautical Systems Div. Aerospace Medical Lab., Wright- Patterson AFB, Ohio
- NSA Number:
- NSA-16-009920
- OSTI ID:
- 4811494
- Report Number(s):
- ASD-TR-61-221; AD-266336
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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