INFLUENCE OF AET UPON THE UPTAKE OF IRON-59 BY THE RED BLOOD CELLS OF GAMMA- IRRADIATED RATS
Technical Report
·
OSTI ID:4035398
Four experiments were conducted to determine the effects of AET (2- aminoethylisothiouronium-bromide) injections on the erythropoietic ability of rats following acute gamma irradiation. Incorporation of Fe/sup 59/ into newly formed red blood cells was used as the criterion of erythropoietic rate. When AET was injected intraperitoneally 15 to 20 min before radiation exposure, little difference resulted in the depression of Fe/sup 59/ uptake 1 to 4 days after irradiation between the nonprotected and AET-protected rats. AET alone had no effect upon the incorporation of Fe/sup 59/. Rats maintained for 31 days after irradiation, however, showed a faster recovery of erythropoiesis when protected with AET. Faster rates of erythropoiesis occurred in-the irradiated rats than in the controls 15 to 18 days after radiation exposure. Those protected with AET incorporated Fe/sup 59/ into newly formed red blood cells at a rate equal to that of the nonirradiated rats 2 to 3 days earlier than did nonprotected rats. (auth)
- Research Organization:
- Wright Air Development Div. Biomedical Lab., Wright-Patterson AFB, Ohio
- NSA Number:
- NSA-15-015416
- OSTI ID:
- 4035398
- Report Number(s):
- WADD-TR-60-395; AD-246348
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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