ANIMAL EXPERIMENTAL STUDIES ON IODINE METABOLISM IN INCREASED AND LOWERED THYROID FUNCTION

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Nuclear-Med.

OSTI ID:4808980

Keiderling, W; Emrich, D; Hahnemann, S; Hoffmann, G

Studies of iodine metabolism under various conditions were carried out in 30 rabbits using a method, described earlier, of comparing after quantitative separation, components of the plasma activity with I/sup 131/-tracer doses. Following stimulation of the thyroid gland with a thyrotropic hormone a shortening of the iodine phase and an earlier onset of the increased secretion of labelled thyroxine and triiodothyronine could be seen. These effects were not fully apparent from the uptake values and the total plasma activity. After acutely reducing the function of the thyroid gland with methylmercaptoimidazole a prolongation of the iodide phase with decreased uptake values and a retardation of the secretion phase with a decreased secretion rate of the total hormone to one third could be observed. These results are discussed in relation to radioiodine uptake tests in human subjects and to the mode of action of thyrotropic hormone and methylmercaptoimidazole. (auth)

• Research Organization: Universitat, Freiburg i.B.
• NSA Number: NSA-16-028718
• OSTI ID: 4808980
• Journal Information: Nuclear-Med., Journal Name: Nuclear-Med. Vol. Vol: 2
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

BIOLOGY AND MEDICINE
BLOOD PLASMA
DRUGS
HORMONES
IMIDAZOLES
IODINE
IODINE 131
MAN
METABOLISM
METHYL RADICALS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
QUANTITY RATIO
RABBITS
THYROID
TRACER TECHNIQUES