THE EFFICACY OF CHEMOTHERAPY IN RADIATION SICKNESS CAUSED BY FRACTIONAL RADIATION
Journal Article
·
· Zhur. Mikrobiol., Epidemiol. i Immunobiol.
OSTI ID:4808302
Studies were conducted in order to find out whether it is possible, with the aid of chemotherapeutic preparations, to prevent the development of bacteremia in animals repeatedly subjected to small doses of ionizing irradiation. The solution of this problem would also make it possible to explain what significance the infectious agent has during radiation sickness caused by fractional irradiation. Nineteen 1 1/2 to 2 years-old monkeys, all carriers of Flexner's bacilli, were subjected to daily gamma irradiation in fractional doses (25.2-26.34 r) from a Co/sup 60/ source up to a total dose of 1000 r. After a 650 r dose had been administered, the monkeys were separated into two groups. Nine of them were treated with antibiotics in combination with vitamins, while the other ten served as controls. The animals were treated for one month. The monkeys were given, simultaneously, 50000 U streptomycin and 100,000 U penicillin intramuscularly, and 50000 U streptomycin and 0.25 g levomycetin orally. Besides antibiotics, once daily the monkeys were eated with 0.1 g vitamin C, 0.5 ml of a 5% vitamin B/sub 1/ solution injected intramuscularly and 5 ml of a 10% calcium gluconate solution taken intravenously. After a short time symptoms of a developing radiation sickness appeared. Changes in the peripheral blood of two monkeys are discussed. The chemotherapeutical results show that the combined administration of antibiotics in radiation sickness in monkeys caused by fractional radiation gives a high therapeutic effect and favors the survival of the majority of the animals irradiated with 1000 r. (OTS)
- Research Organization:
- Inst. of Experimental Pathology and Therapy, AMS USSR
- NSA Number:
- NSA-16-026875
- OSTI ID:
- 4808302
- Journal Information:
- Zhur. Mikrobiol., Epidemiol. i Immunobiol., Journal Name: Zhur. Mikrobiol., Epidemiol. i Immunobiol. Vol. Vol: No. 10
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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