INFLUENCE OF RADIATION DOSE ON INDUCTION OF THE FOREIGN SPLEEN REACTION IN F$sub 1$ HYBRID MICE
Journal Article
·
· Transplantation Bull.
OSTI ID:4804699
Parental spleen cells were injected into several strains of F/sub 1/ hybrid mice given 0 to 900 r of whole-body x radiation, and the survival, clinical appearance, and histologic changes in the recipients were studied. With two exceptions there was a threshold level of radiation below which there was no mortality. This radiation level varied with the donorrecipient strain combination, being lower in those with more marked histoincompatibility. The mortality was associated with a granulomatous reaction in lymphoid organs, atrophy of hemopoietic tissues, and outward signs of illness. Mortality occurred earlier following higher irradiation doses. Strain variations in ultimate mortality were noted. (auth)
- Research Organization:
- Oak Ridge National Lab., Tenn.
- NSA Number:
- NSA-16-026838
- OSTI ID:
- 4804699
- Journal Information:
- Transplantation Bull., Journal Name: Transplantation Bull. Vol. Vol: 30
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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