PROLONGED SURVIVAL OF SKIN HOMOGRAFTS IN ADULT MICE FOLLOWING SUB-LETHAL IRRADIATION, INJECTION OF DONOR-STRAIN SPLEEN CELLS AND ADMINISTRATION OF A-METHOPTERIN

Journal Article · Sat Aug 18 00:00:00 EDT 1962 · Nature

DOI:https://doi.org/10.1038/195727a0· OSTI ID:4804605

Woodruff, M F.A.

Sixteen A-strain male mice were given 500 r wholebody irradiation, followed by an intravenous injection of 150 million nucleated spleen cells from male CBA mice twice daily for two days, startiag on the day of irradiation. Four mice received no further treatment; the remainder were given A-methopterin in a dosage of 1.5 mu g/g bodyweight every 2 days for six doses, starting 2, 6, or 10 days after irradiation. Four weeks after irradiation all surviving mice received a homograft of skin from a CBA male donor. The incidence of fatal graft- versus-host disease was greatly reduced by administration of A-methopterin starting on day 2, and reduced to a lesser extent by administration of the drug starting on day 6. (P.C.H.)

• Research Organization: Univ. of Edinburgh, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-026874
• OSTI ID: 4804605
• Journal Information: Nature, Vol. Vol: 195; Other Information: Orig. Receipt Date: 31-DEC-62
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
ABSORPTION
BODY
CARBON
CHEMICALS
COINCIDENCE METHODS
COSMIC RADIATION
COUNTERS
DISTRIBUTION
ELASTICITY
ELECTRONS
ENERGY
ENERGY RANGE
IMMUNITY
INTERACTIONS
LEAD
LEVELS
MEASURED VALUES
MICE
MUONS
NUCLEI
NUCLEONS
PHOTONS
PIONS
PIONS-NEUTRAL
PRODUCTION
RADIATION DOSES
SCATTERING
SKIN
SPLEEN
TRANSIENTS
TRANSPLANTS