ENHANCED SURVIVAL OF SKIN HOMOGRAFTS IN MICE WITH A BACTERIAL INFECTION

Journal Article · Tue Mar 31 04:00:00 EST 1964 · Annals of the New York Academy of Sciences

DOI:https://doi.org/10.1111/j.1749-6632.1964.tb53601.x· OSTI ID:4026444

Iossifides, I. A.; Gutzait, L.; Brand, M.; Tocantins, L. M.

During an unrelated experiment, A-strain mice injected with 0.5 x 10⁹ C³H/He splenic cells were given skin homografts from the original spleen donor. In 4 of the 14 grafted animals prolongation of the homograft survival coincides with the presence of a large, chronic, intraperitoneal abscess caused by a Corynebacterium species. The observation suggested the possibility of a relation between bacterial infection and the homograft survival. In attempts to investigate this possibility A mice were inoculated intraperitoneally with the same organism. In only 9 of 67 infected animals a large abscess was formed; these nine mice showed an average of five days' increase in the mean homograft survival-time. Splenectomies did not alter the results. The number of experiments is small for statistical analysis but an indication is offered that within the anlmal an interdependency and a mutual influence may exist between immunologic reactions against bacterial and against tissue antigens. (auth)

• Research Organization: Jefferson Medical Coll., Philadelphia
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-019511
• OSTI ID: 4026444
• Journal Information: Annals of the New York Academy of Sciences, Journal Name: Annals of the New York Academy of Sciences Journal Issue: 1 Vol. 114; ISSN 0077-8923
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
ANTIGENS
BACTERIA
BIOLOGY
BIOLOGY AND MEDICINE
IMMUNITY
INFECTIONS
INTESTINE
MICE
PHYSIOLOGY
SKIN
SPLEEN
SURGERY
SUSPENSIONS
TESTING
TISSUES
TRANSPLANTS