EFFECT OF THE PRELIMINARY ADMINISTRATION OF RADIOACTIVE ISOTOPES ON THE COMPOSITION OF PERIPHERAL BLOOD AND THE SURVIVAL OF ANIMALS SUBSEQUENTLY X-IRRADIATED WITH A LETHAL DOSE

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Byul. Eksperim. Biol. i Med.

OSTI ID:4708906

Lomonos, P I

The administration of radioactive isotopes prior to irradiation with lethal doses in order to increase survival rate, was studied. The experiments were carried out on albino rats (180 to 200 g) and albino mice (20 to 25 g). The animals received I/sup 131/, P/sup 32/, and methionine-S/sup 35/ prior to x irradiation. The rats were irradiated with 800 r and the mice with 600 r, which corresponded to LD/sub 60/30/. The time interval between administration of the radioisotopes and subsequent irradiation varied according to the greatest functional changes observed in various functional systems. The administration of the radioisotopes 15, 45, and 55 days prior to a wholebody x irradiation of rats increased their survival rate by 5 to 23%. The effect of the administration of methionine was greater the longer the time-interval between its administration and the subsequent irradiation. Administration of methiorine in mice 15 days prior to irradiation eliminated the radiation injury caused by 800 r. Methionine also had a good effect on the blood picture; the number of WBC, especially of netrophiles and eosinophiles, increased. (P.C.H.)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-012148
• OSTI ID: 4708906
• Journal Information: Byul. Eksperim. Biol. i Med., Journal Name: Byul. Eksperim. Biol. i Med. Vol. Vol: 53: No. 2
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINO ACIDS
BIOLOGY AND MEDICINE
EOSINOPHILS
IODINE 131
LETHAL DOSE
LEUCOCYTES
METHIONINE
MICE
NEUTROPHILS
PHOSPHORUS 32
QUANTITY RATIO
RADIATION PROTECTION
RATS
SULFUR 35
X RADIATION