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A CYTOLOGICAL OBSERVATION ON CHROMOSOME BREAKS IN MN LYMPHOSARCOMA CELLS INDUCED BY X-IRRADIATION

Journal Article · · Wakayama Igaku (Japan)
OSTI ID:4795267
Chromosomal aberration in MN lymphosarcoma, following exposure to ionizing radiation, is reported. Wholebody x irradiations were given to tumor- bearing mice. The tumor stem cells of MN lymphosarcoma were characterized by 40 rod-shaped chromosomes. The most suitable x-ray dose for cytological observation was 100 r. As a standard for measurement of each chromosome, the largest chromosome length in metaphasic plates of stem cells was used. The chromosome length of stem cells was statistically classified into 7 groups. In this connection the chromosome, havlng the ordered length of 0.9, was sensitive to x irradiation, and the radiosensitive region was close to the middle portion of the arm. As a chromosome aberration, bridge formation and chromosomal stickiness were also found. (Abstr. Japan Med., 2, No. 2, Feb. 1962)
Research Organization:
Wakayama Medical Coll., Japan
NSA Number:
NSA-16-014583
OSTI ID:
4795267
Journal Information:
Wakayama Igaku (Japan), Journal Name: Wakayama Igaku (Japan) Vol. Vol: 11: No. 2; ISSN WKMIA
Country of Publication:
Country unknown/Code not available
Language:
English

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