STUDY ON THE BEGINNING OF THYMUS ATROPHY AFTER RONTGEN IRRADIATION. III. THE BINDING BETWEEN DEOXYRIBONUCLEIC ACID AND PROTEIN IN RADIATION DAMAGE OF TELL NUCLEI

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Strahlentherapie (West Germany)

OSTI ID:4792328

Hagen, U

The bonds between deoxyribonucleic acid and protein are loosened or destroyed in the nuclei of the thymus cells of rats after a whole-body irradiation. This radiation effect can be seen even before cell death, during the second hour after irradiation. By determination of certain nucleoprotein preparations before and after a whole-body irradiation it was found that this binding, which is damaged by irradiation is very important for the maintenance of chromosome structures. The radiation effect is erased, if calcium-ions are added to the damaged nucleoprotein. The amount of the calcium-ions, necessary, is proportional to the radiation dose. It is possible that calcium causes a reunion of the loosened bindings between DNA and protein. (auth)

• Research Organization: Universitat, Freiburg i. B.; and Heiligenberg-Instituts, Ger.
• NSA Number: NSA-16-016233
• OSTI ID: 4792328
• Journal Information: Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 117; ISSN STRAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
CALCIUM
CELL NUCLEI
CYTOLOGY
IONS
NUCLEIC ACIDS
PROTEINS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RATS
THYMUS
X RADIATION