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Title: HISTOPATHOLOGICAL STUDIES ON THE EFFECT OF IRRADIATION WITH VARIOUS DOSES OF X-RAYS UPON THE HEMOPOIETIC TISSUE OF YOUNG MICE. III. CHANGES IN EXTRAMEDULLARY HEMOPOIETIC TISSUE OF SPLEEN AND SOME CONSIDERATION ON THEIR SIGNIFICANCE

Abstract

Histopathological observation was carried out on the changes of the extramedullary hemopoietic tissue of spleen of young mice which had been irradiated with from 60 to 600 r of x rays. In addition to the observation, discussion was made on correlation between these changes and those in the bone marrow and on such correlation in connection with changes in the peripheral blood. Histopathological pictures of damage produced by various dose levels of x rays in the extramedullary hemopoietic tissue of the spleen were not so greatly different from those in the bone marrow. Generally speaking, the extramedullary hemopoietic tissue of the spleen began to be regenerated almost at the same time as the bone marrow. After that, however, it revealed more rapid proliferation than the bone marrow. Therefore, it fell into a state of hyperplasia prior to the recovery of the bone marrow. The larger the dose of irradiation applied, the longer this hyperplastic state lasted. Eventually the splenic hemopoietic tissue was restored nearly to normal conditions at the same time with the bone marrow. Such a difference as this between the two types of tissue during the phase of regeneration was displayed most remarkably in erythroblasts. This tendency wasmore » distinct especially after exposure to a dose of x rays not less than 300 r. From the findings on the hemopoietic tissue and peripheral blood, it is presumed that the extramedullary hemopoietic tissue of the spleen compensated the dysfunction of the bone marrow and played an important role in the recovery or prevention of decrease in number of peripheral erythrocytes and the recovery in the early period of granulocytes when animals exposed to x rays were at the stage of recovery from radiation injury. From these results, it is assumed that the extramedullary hemopoietic tissue of the spleen of the young mouse retains a hemopoietic function to some extent even under normal conditions. (auth)« less

Authors:
Publication Date:
Research Org.:
Originating Research Org. not identified
OSTI Identifier:
4791629
NSA Number:
NSA-16-028797
Resource Type:
Journal Article
Journal Name:
Natl. Inst. Animal Health Quart. (Tokyo)
Additional Journal Information:
Journal Volume: Vol: 2; Other Information: Orig. Receipt Date: 31-DEC-62
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
BIOLOGY AND MEDICINE; AGE; BLOOD; BLOOD FORMATION; BONE MARROW; CYTOLOGY; ERYTHROCYTES; MICE; RADIATION DOSES; RADIATION EFFECTS; RADIATION INJURIES; RECOVERY; REGENERATION; SPLEEN; TISSUES; X RADIATION

Citation Formats

Takahashi, I. HISTOPATHOLOGICAL STUDIES ON THE EFFECT OF IRRADIATION WITH VARIOUS DOSES OF X-RAYS UPON THE HEMOPOIETIC TISSUE OF YOUNG MICE. III. CHANGES IN EXTRAMEDULLARY HEMOPOIETIC TISSUE OF SPLEEN AND SOME CONSIDERATION ON THEIR SIGNIFICANCE. Country unknown/Code not available: N. p., 1962. Web.
Takahashi, I. HISTOPATHOLOGICAL STUDIES ON THE EFFECT OF IRRADIATION WITH VARIOUS DOSES OF X-RAYS UPON THE HEMOPOIETIC TISSUE OF YOUNG MICE. III. CHANGES IN EXTRAMEDULLARY HEMOPOIETIC TISSUE OF SPLEEN AND SOME CONSIDERATION ON THEIR SIGNIFICANCE. Country unknown/Code not available.
Takahashi, I. Mon . "HISTOPATHOLOGICAL STUDIES ON THE EFFECT OF IRRADIATION WITH VARIOUS DOSES OF X-RAYS UPON THE HEMOPOIETIC TISSUE OF YOUNG MICE. III. CHANGES IN EXTRAMEDULLARY HEMOPOIETIC TISSUE OF SPLEEN AND SOME CONSIDERATION ON THEIR SIGNIFICANCE". Country unknown/Code not available.
@article{osti_4791629,
title = {HISTOPATHOLOGICAL STUDIES ON THE EFFECT OF IRRADIATION WITH VARIOUS DOSES OF X-RAYS UPON THE HEMOPOIETIC TISSUE OF YOUNG MICE. III. CHANGES IN EXTRAMEDULLARY HEMOPOIETIC TISSUE OF SPLEEN AND SOME CONSIDERATION ON THEIR SIGNIFICANCE},
author = {Takahashi, I},
abstractNote = {Histopathological observation was carried out on the changes of the extramedullary hemopoietic tissue of spleen of young mice which had been irradiated with from 60 to 600 r of x rays. In addition to the observation, discussion was made on correlation between these changes and those in the bone marrow and on such correlation in connection with changes in the peripheral blood. Histopathological pictures of damage produced by various dose levels of x rays in the extramedullary hemopoietic tissue of the spleen were not so greatly different from those in the bone marrow. Generally speaking, the extramedullary hemopoietic tissue of the spleen began to be regenerated almost at the same time as the bone marrow. After that, however, it revealed more rapid proliferation than the bone marrow. Therefore, it fell into a state of hyperplasia prior to the recovery of the bone marrow. The larger the dose of irradiation applied, the longer this hyperplastic state lasted. Eventually the splenic hemopoietic tissue was restored nearly to normal conditions at the same time with the bone marrow. Such a difference as this between the two types of tissue during the phase of regeneration was displayed most remarkably in erythroblasts. This tendency was distinct especially after exposure to a dose of x rays not less than 300 r. From the findings on the hemopoietic tissue and peripheral blood, it is presumed that the extramedullary hemopoietic tissue of the spleen compensated the dysfunction of the bone marrow and played an important role in the recovery or prevention of decrease in number of peripheral erythrocytes and the recovery in the early period of granulocytes when animals exposed to x rays were at the stage of recovery from radiation injury. From these results, it is assumed that the extramedullary hemopoietic tissue of the spleen of the young mouse retains a hemopoietic function to some extent even under normal conditions. (auth)},
doi = {},
journal = {Natl. Inst. Animal Health Quart. (Tokyo)},
number = ,
volume = Vol: 2,
place = {Country unknown/Code not available},
year = {1962},
month = {1}
}