STUDIES OF STRONTIFICATION IN VITRO
Using rachitic epiphyseal cantilage from rats, a study was made of strontification and calcification in vitro. The formation of a crystal from a solution takes place in 3 stages, (1) the formation of nuclei of crystallization (nucleation); (2) growth of crystals upon these nuclei; and (3) the cessation of crystal growth. These studies with rachitic rat cartilage indicate that in solutions of Ca and phosphate, nucleation takes place with relative ease. Nucleation takes place with Sr and phosphate, but is more difficult to achieve. Small amounts of Ca inhibit nucleation with Sr but once Sr phosphate nuclei have been produced, Ca ion does not inhibit the crystal growth of Ca phosphate. X-ray diffraction studies indicate that the crystals are Sr hydroxyapatite and Ca hydroxyapatite. (H.H.D.)
- Research Organization:
- Jewish Hospital, Brooklyn
- NSA Number:
- NSA-17-001212
- OSTI ID:
- 4789556
- Journal Information:
- Clin. Chem., Journal Name: Clin. Chem. Vol. Vol: 8
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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