ON THE UPTAKE OF RADIOACTIVE CALCIUM AND STRONTIUM IN THE SKELETON OF NORMAL AND RACHITIC RATS
The uptake of Ca/sup 47/ and Sr/sup 85/ given intravenously to normal and rachitic rats was followed by measurements of the activity of the tail and total body of living animals. During the first hours after injection, the total- body activity decreased slightly because of excretion of the radioisotopes, while the activity of the tail rose on account of their accumulation in bone. The uptake in bone the first hr after injection was the same in normal and rachitic rats, but in the rachitic rats it decreased within 8 hr to approximates 1/2 the maximum value. Besides the diffuse uptake of isotopes in the bone tissue itself, demonstrated in both the normal and the rachitic bone, a heavy accumulation of isotopes took place on the metaphyseal side of the epiphyseal line in the normal bone, but in the rachitic bone uptake was lacking. The results indicate that the immediate uptake of radioactive Ca and Sr in bone, as seen during the first hours in both normal and rachitic animals, is due mainly to a reversible exchange process, as shown by the decrease in the activity in the rachitic animals during the succeeding hours. Only part of the activity taken up at the epiphyseal line was retained by the skeleton by later accretion processes. Thus, 2 phases of incorporation of the isotopes must be considered: a rapid, reversible exchange between blood and bone tissue, and a secondary, slower incorporation in bone mineral. (H.H.D.)
- Research Organization:
- Orthopaedic Hospital, Copenhagen
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-015591
- OSTI ID:
- 4749142
- Journal Information:
- Acta Orthopaed. Scand., Journal Name: Acta Orthopaed. Scand. Vol. Vol: 30
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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