INFLUENCE OF AGE AND STRAIN OF X-IRRADIATED MICE ON THE APPEARANCE OF LEUKEMIA AND LYMPHOID TUMORS

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Bull. Assoc. Franc. Etudes Cancer

OSTI ID:4789107

Riviere, M R; Chourolinkov, I; Marty, C; Guerin, M

A single 300-r whole-body dose was given to mice of 3 strains (C3H, IC, XLII) and of 2 age groups (4-6 weeks and 4-6 months). Both age and strain influenced the incidence of leukemia and lymphoid tumors following irradiation. The incidence was higher in young than old mice; the XLII strain was resistant and the IC strain relatively susceptible. The incidence of leukemia or lymphosarcoma in young and old mice, respectively, was 12.2 and 6.8% in the IC strain, 0 and 2.6% in the C3H strain, and 0 and 0% in the XLII strain, The respective incidences in control animals were mediastinal in location. By injection of an extract prepared from lymphomas of AKR mice, combined with irradiation, leukemia or lymphosarcoma could be induced in the resistant XLII stain. Young and old rats developed malignancy in 6.8 and 3.1%, but lymphoma extract alone had no effect. (H.H.D.)

• Research Organization: Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
• NSA Number: NSA-17-001276
• OSTI ID: 4789107
• Journal Information: Bull. Assoc. Franc. Etudes Cancer, Journal Name: Bull. Assoc. Franc. Etudes Cancer Vol. Vol: 49
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BODY
CARCINOGENESIS
CHEMICAL REACTIONS
GAMMA RADIATION
LEUKEMIA
LYMPH SYSTEM
LYMPHOSARCOMAS
MEDIASTINUM
MICE
QUANTITY RATIO
RADIATION CHEMISTRY
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
REACTION KINETICS
RIBONUCLEIC ACID
SODIUM COMPOUNDS
SOLUTIONS
TRANSPLANTS
TUMORS
X RADIATION