ROLE OF IRRADIATION WITH X RAYS ON THE APPEARANCE OF MAMMARY OR OVARIAN TUMORS ACCORDING TO THE STRAIN AND AGE OF THE MICE

Journal Article · Sun Apr 01 04:00:00 EST 1962 · Bull. Assoc. France. Etude Cancer

OSTI ID:4738427

Riviere, M -R; Chouroulinkov, I; Marty, C; Guerin, M

Prepubertal and adult mice (aged 4 to 6 weeks and 4 to 6 months, respectively) were exposed to a single whole-body 300-r dose of x rays and development of the tumors was followed. Three strains of mice were studied: IC strain, in which mammary tumors are rare; C3He/A, which lacks the milk factor; and XLII, which never develops mammary tumor. Only a few mammary tumors developed and only in the IC strain; the incidence rate was 6% in nonirradiated controls and 2% in both of the irradiated groups. This confirms previous findings that irradiation retards the appearance of mammary tumors. Ovarian tumors were completely lacking in nonirradiated mice of the IC and XLII strains, but present in C3He/A cortrols in 6 and 9% of the young and old groups, respectively. It also appeared that younger mice were more susceptible to x-ray induction of ovarian tumors. Two types of ovarian tumors predominated, namely, folliculotubular and luteal. (TCO)

• Research Organization: Institut de Recherches Scientifiques sur le Cancer, Villejuif, France
• NSA Number: NSA-17-017819
• OSTI ID: 4738427
• Journal Information: Bull. Assoc. France. Etude Cancer, Journal Name: Bull. Assoc. France. Etude Cancer Vol. Vol: 49
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
CARCINOGENESIS
GLANDS
GONADS
MAMMARY GLANDS
MICE
RADIATION DOSES
RADIATION EFFECTS
TUMORS
X RADIATION