The Evaluation of X-ray-induced Chromosome Aberrations in Cell-cultures of the Chinese Hamster

Journal Article · Wed Nov 01 04:00:00 EST 1961 · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine

DOI:https://doi.org/10.1080/09553006114551111· OSTI ID:4786975

Greenblatt, Charles L.

The sources of variation in the evaluation of x-rayinduced chromosome aberrations in cell cultures of Chinese hamster (Cricetulus griseus) are discussed. The most important of these, in determining the nature and number of the lesions, seems to be the time of observation in relation to the growth of the cells. The number of visibly damaged mitoses in the first generation after irradiation in cells in metaphase and anaphase is consistent with the number of cells incapable of proliferation. From calculations of the number of chromosome aberrations occurring in these cells and their survival-curve, a working hypothesis is proposed which seems consistent with many features of cellular death due to radiation. (auth)

• Research Organization: National Inst. of Arthritis and Metabolic Diseases, Bethesda, Md.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-012912
• OSTI ID: 4786975
• Journal Information: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 2 Vol. 4; ISSN 0020-7616
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CHROMOSOMES
LIFETIME
MITOSIS
QUANTITATIVE ANALYSIS
RADIATION INJURIES
X RADIATION