Metaphase chromosome aberrations in the Chinese hamster liver in vivo after either acute or fractionated $sup 60$Co irradiation

Journal Article · Tue Jan 01 04:00:00 EST 1974 · Radiat. Res., v. 57, no. 1, pp. 187-194

OSTI ID:4344664

McKay, L R; Shaw, S M; Brooks, A L

The frequency, type, and persistence of metaphase chromosome aberrations induced in the liver by single acute or fractionated whole-body /sip 60/Co irradiation in young adult (minimum age: 8 weeks) female Chinese hamsters were determined. Partial hepatectomy was used to stimulate the liver into active cellular proliferation at a variety of times after exposure. Minimal or no change in the aberration frequency as seen in metaphase spread preparations was obscrved up to 36 weeks after a single acute exposure of 400 R. Cumulative exposures of up to 1000 R delivered at a rate of 8 R/min in daily fractions of either 4 or 8 R were correlated with the number of chromosomal aberrations observed per cell. The observed aberration frequency was directly related to cumulative exposure and adequately described by a linear equation of the form Y = a + bX. where the coefficients were a = 0.003 or 0.029 and b = 2.62 x 10/sup -4/ or 2.26 x 10/sup -4/ aberrations/cell/R in animals irradiated at 4 or 8 R/day, respectively. A single acute exposure to /sup 60/Co was shown to be about three times as effective for aberration production as exposure to daily fractions, which is an indication that chromosome repair may have occurred in the liver cells of animals repeatedly irradiated. (auth)

• Research Organization: Purdue Univ., Lafayette, IN
• NSA Number: NSA-29-018640
• OSTI ID: 4344664
• Journal Information: Radiat. Res., v. 57, no. 1, pp. 187-194, Journal Name: Radiat. Res., v. 57, no. 1, pp. 187-194; ISSN RAREA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*CHROMOSOMAL ABERRATIONS-- RADIOINDUCTION
*LIVER-- CHROMOSOMAL ABERRATIONS
ACUTE IRRADIATION
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
FRACTIONATED IRRADIATION
GAMMA RADIATION
HAMSTERS
HEPATECTOMY
IN VIVO
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOTON BEAMS
RADIATION DOSES RADIOINDUCTION