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LIVER CELL PROLIFERATION IN X-IRRADIATED RATS AFTER SINGLE AND REPETITIVE PARTIAL HEPATECTOMY

Technical Report ·
OSTI ID:4119396
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It has been shown previously that following exposure to x radiation, abnormal mitoses occur in regenerating liver. The behavior of this system in the rat under repeated stimuli to proliferation has been studied to determine the regenerative behavior of such a tissue containing cells with demonstrably damaged nuclear-mitotic apparatus. Irradiation involved two 400 r exposures three weeks apart. Successive pantial hepatectomies were performed 8 weeks, 11 weeks, and 14 weeks after the last exposure. Liver weights recovered to within 15 to 20% of controls after the first, as well as after subsequent partial hepatectomies. Radiation exposure does not affect liver weight to body weight ratios under those conditions. By contrast, mitotic index in the irradiated rats is consistently 50 to 60% below values in nonirradiated controls. Less than 10% of the mitoses in regenerating liver of nonirradiated rats were visibly aberrant, whereas 75 to 85% of the mitoses in all postradiation animals were abnormal. The discrepancy between mass regeneration and mitotic frequency, and the effect of a very high proportion of cells with damaged mitoticnuclear apparatus on growth potential are discussed. (auth)
Research Organization:
Naval Radiological Defense Lab., San Francisco
NSA Number:
NSA-15-007198
OSTI ID:
4119396
Report Number(s):
USNRDL-TR-489
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
LIVER
MITOSIS
RATS
REGENERATION
SURGERY
X RADIATION