REPARATIVE REGENERATION OF THE LIVER OF THE RAT AFTER LOCAL EXPOSURE TO X RADIATION

Journal Article · Mon Jul 01 04:00:00 EDT 1963 · Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals

OSTI ID:4672089

Kalashnikova, M M

The effect of local irradiation on the regenerative power of the liver was investigated on male white rats. The animals were subjected to a single, 1000-r irradiation of the liver. One day after the exposure an operative injury was made at the right side of the liver; operated but not irradiated and irradiated but not operated animals were used as control. Comparison of the results obtained with the various series showed that exposure of the liver to 1000 r causes the formation of small necrotic centers, vacuolization of the cytoplasm, disturbances in the cell structure and atypical mitoses; therefore the liver cannot be considered a radiation-resistant organ. The effect of radiation during regeneration after partial hepatectomy is manifested in the slowing down of the leukocytic reaction, appearance of atypical mitoses, and in the case of young animals, by edema; all these reactions tend to slow down the recovery process. The animals with a liver which was partially hepatectomized after irradiation did not exhibit vacuolization of the cytoplasm and the cell structure was disturbed to a lesser extent. This might be to the fact that plastic processes involved in the regeneration of the liver weaken the development of pathological processes. (TTT)

• Research Organization: Severtsov Inst. of Animal Morphology, Academy of Sciences, USSR
• NSA Number: NSA-17-033670
• OSTI ID: 4672089
• Journal Information: Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals, Journal Name: Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals Vol. Vol: 151; ISSN DANKA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

BIOLOGY AND MEDICINE
CONTROL
CYTOLOGY
LEUCOCYTES
LIVER
MITOSIS
RADIATION INJURIES
RADIOSENSITIVITY
RATS
RECOVERY
REGENERATION
SEX
SURGERY
X RADIATION