Effects of Phencyclidine on the Radiosensitivity of Mice

Journal Article · Sat Sep 22 04:00:00 EDT 1962 · Nature (London)

DOI:https://doi.org/10.1038/1951172a0· OSTI ID:4778255

WILKINS, J. H.; BARNES, J. H.

Experiments were conducted to determine the protective effects of phencyclidine, a psychotropic drug. When R mice were given 2 to 60 mg/kg phencyclidine intraperitoneally and irradiated with 1025-r x rays 15 min later, no protective effect was detected. When mice were given 4 mg/kg phencyclidine and irradiated with doses of 650 to 950 r 0.5 hr later, a protective effect was found in the mortality responses. The LD/sub 50/ for 30 days was calculated to be 828 r for the phencyclidine-treated (4 mg/kg) mice, as compared with 752.5 r for the controls. (D.L.C.)

• Research Organization: Medical Research Council, Harwell, Berks, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-031522
• OSTI ID: 4778255
• Journal Information: Nature (London), Journal Name: Nature (London) Journal Issue: 4847 Vol. 195; ISSN 0028-0836
• Publisher: Nature Publishing Group
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
DRUGS
LETHAL DOSE
MICE
RADIATION DOSES
RADIATION PROTECTION
X RADIATION