RADIOACTIVE METAL MOBILIZATION

Journal Article · Fri Sep 01 00:00:00 EDT 1961 · Federation Proc.

OSTI ID:4777710

Catsch, A

The potentialities, drawbacks, and limitations of ethylenediaminetetraacetic acid (EDTA) in the removal of radioaetive metals are discussed. The biological effectiveness of EDTA is compared with that of several other chelating agents, with emphasis on CaNa/sub 3/-diethylene- triaminepentaacetic acid (DTPA). Data are tabulated on the effect of DTAA and EDTA on the retention of Y/sup 91/, Ce/sup 144/, Th/sup 234/, Pu/sup 23 and Am/ sup 241/ in rats. Data are also tabulated on the effects of EDTA, DTPA, hydroxyethylenediaminetriacetic acid (HEDTA), and 1-2,- diaminecyclohexanetetraacetic acid (CDTA) on the retention of Ce/sup 144/ in the organs of rats, the effects of Na polyphosphate (Graham's salt) on the retention of Y/sup 91/, Ce/sup 144/, and Pusup 239/ in the liver, kidneys, and skeleton of rats. The effects of certain esterified polyamino acids are discussed and data are presented on the effects N - (2-hydroxyethyl)ethylenediamine-N,-N,N - triacetic acid (HEDTA) and derivative and N',N -bis(2- hydroxycyclohexyl)ethylenediamine-N,N -diacetic acid (DOC) administered as calcium sodium chelate (Ch) or respective ester lactone (E), on the distribution of Ce/sup 144/ and Y/sup 91/ in the organs of the rat. The effects of individual chelating agents on the removal of Sr/up 89/ and Sr/sup 90/ are also reviewed. Reaetion mechanisms involved and the effects of dose, time of administration, and chemical composition on the biological effectiveness of a number of chelating agents are discussed. It is concluded that DTPA is one of the more effective chelating agents. (C.H.)

• Research Organization: Inst. of Radiobiology, Karlsruhe, Ger.
• NSA Number: NSA-16-029327
• OSTI ID: 4777710
• Report Number(s): KFK-76
• Journal Information: Federation Proc., Vol. Vol: 20: Suppl. No. 10; Other Information: KFK-76. Orig. Receipt Date: 31-DEC-62
• Country of Publication: Germany
• Language: English

Related Subjects

METALS, CERAMICS, AND OTHER MATERIALS
AMERICIUM 241
AMINES
BIOLOGY
BONES
CERIUM 144
CHELATES
COMPLEXES
EDTA
EFFICIENCY
ESTERS
KIDNEYS
LIVER
ORGANIC ACIDS
PLUTONIUM 239
QUALITATIVE ANALYSIS
RADIATION DOSES
RADIOBIOLOGY
RATS
REACTION KINETICS
SODIUM PHOSPHATES
STRONTIUM 89
STRONTIUM 90
THORIUM 234
YTTRIUM 91