Further Observations on Induction of Tumors in Mice with Radioactive Thymidine
Journal Article
·
· Experimental Biology and Medicine
Thymidine labeled with tritium or with carbon-14, when incorporated into DNA of proliferating cells, produces a selective mode of irradiation of cells and cell nuclei. Single and multiple injections of radioactive thymidine have been found to shorten the life span and to produce an increased incidence of tumors in CaFl mice. The incidence of tumoi s increased with dose and it was greater in animals injected as young adults than in animals injected later in life. Labeling of embryos in utero with tritiated thymidine likewise increased the incidence of malignant tumors.
- Research Organization:
- Northwestern Univ. Medical School, Chicago; and Argonne National Lab., Ill.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-031498
- OSTI ID:
- 4776831
- Journal Information:
- Experimental Biology and Medicine, Journal Name: Experimental Biology and Medicine Journal Issue: 4 Vol. 110; ISSN 1535-3702
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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