STUDY OF THE MITOTIC INDEX AND OF SOME MEDULLARY ELEMENTS IN FIVE SUBJECTS EXPOSED TO WHOLE-BODY RADIATION THERAPY

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Annales de Radiologie (France)

OSTI ID:4776707

Davidoff-Alibert, S; Dormont, J; Jammet, H; Parmentier, N C; Tubiana, M

The mitotic index of the marrow in five subjects receiving whole-body therapeutic irradiation in a uniform dose was followed up by repeated marrow puncture. In two patients who received 400 and 450 rads, the mitotic index fell little up to the 20th day, and then fell to zero. It then rose rapidly again to a value above normal. This was accompanied by a rapid increase in the number of blood cells in the peripheral blood. In patients who received 100 and 250 rads, the evolution took place in three phases: an initial fall of the naitotic index, a transitory rise, and then a second fall. The rise in the number of blood cells occurred during a phase in which the marrow was aplastic, In the patient who received 50 rads, only a slight and late variation of the mitotic index was observed. The higher the dose, the earlier is the blood aplasia and the earlier the marrow and blood regeneration. (auth)

• Research Organization: Commissariat a l'Energie Atomique, Saclay, France
• NSA Number: NSA-17-001257
• OSTI ID: 4776707
• Journal Information: Annales de Radiologie (France), Journal Name: Annales de Radiologie (France) Vol. Vol: 5; ISSN ARDOA
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

BIOLOGY AND MEDICINE
BLOOD CELLS
BODY
BONE MARROW
CYTOLOGY
MAN
MICROSCOPY
MITOSIS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIOTHERAPY