HEMATOLOGICAL EVOLUTION OF PATIENTS EXPOSED TO WHOLE-BODY IRRADIATION FOR ORGAN TRANSPLANTATION (in French)
Journal Article
·
· Annales de Radiologie (France)
OSTI ID:4140849
Single, uniform, whole-body irradiation, at doses from 400 to 500 rads, produces a prolonged aplasia of the bone marrow and circulating blood and a considerable change in the general condition of the patient. However, none of the seven patients so treated and followed for a sufficient period of time has died from the effects of the irradiation. This is due, no doubt, to the exercise of aseptic precautions that would seem to have prevented exogenous infections. In the comparison of patients receiving different doses, it was found that the higher the dose, the faster was the fall in the blood cell count and the more marked was the marrow aplasia. Within the limits of the doses used, it appears that regeneration was faster for those patients whose aplasia occurred the earliest. The effects of a dose of 400 rads in one treatment or of a total dose of 450 rads in two treatments separated by an interval of several days would seem to be comparable, except, possibly, for the lymphocyte counts upon which the fractionated doses produced less lasting changes. Finally, irradiation seemed to have improved, at least temporarily, the tolerance of all the patients for kidney transplants. (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-18-003510
- OSTI ID:
- 4140849
- Journal Information:
- Annales de Radiologie (France), Journal Name: Annales de Radiologie (France) Vol. Vol: 6; ISSN ARDOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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