Endolymphatic irradiation with $sup 198$Au and $sup 32$P as immunosuppression in renal transplantion. The effect on hematologic and immunobiologic parameters

Journal Article · Sun Feb 01 04:00:00 EST 1976 · Radiat. Res., v. 65, no. 2, pp. 371-385

OSTI ID:4037766

Birkeland, S A; Moesner, J; Kalnaes, O; Jensen, T S

Twenty patients with end stage renal disease awaiting kidney transplantation were treated with radioisotopes in an investigation of the immunosuppressive effect of endolymphatic irradiation. Twelve patients received $sup 198$Au and eight were treated with $sup 32$P. The isotopes were injected into lymph vessels in the foot and localized in the pelvic lymph nodes with only an extremely small release to the blood and urine. The doses given were 2-7.5 mCi $sup 198$Au or 0.4-1.5 mCi $sup 32$P. The accumulated dose in the lymph nodes was calculated to be approximately 35,000 rad for $sup 198$Au and approximately 150,000 rad for $sup 32$P. The blood activity was 1.0-0.2 rad. The dose to a kidney graft was calculated to be approximately 20 rad, and the dose to a lymphocyte in the first 6 hr after injection approximately 1500 rad. The results obtained were lymphocytopenia and a depressed immune response measured with blast transformation tests after stimulation with mitogens, antigens, and allogene cells in mixed lymphocyte culture. No effect was observed on bone marrow, immunoglobulins, complements, liver enzymes, spleen-size, or liver size. A small transient fall in erythrocyte count was seen but otherwise no side effects were demonstrated. Thus, the treatment given, with maximum permissible doses, had an effect on the immune response, but as this effect only lasts for a few weeks the treatment has little practical applicability in kidney transplantation. (auth)

• Research Organization: Odense Univ. Hospital, Denmark
• NSA Number: NSA-33-029770
• OSTI ID: 4037766
• Journal Information: Radiat. Res., v. 65, no. 2, pp. 371-385, Journal Name: Radiat. Res., v. 65, no. 2, pp. 371-385; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

*GOLD 198-- BIOLOGICAL RADIATION EFFECTS
*IMMUNE REACTIONS-- BIOLOGICAL RADIATION EFFECTS
*IMMUNOSUPPRESSION
*KIDNEYS-- TRANSPLANTS
*LYMPH NODES-- BIOLOGICAL RADIATION EFFECTS
*LYMPH VESSELS-- BIOLOGICAL RADIATION EFFECTS
*PHOSPHORUS 32-- BIOLOGICAL RADIATION EFFECTS
560161* --Biomedical Sciences
Applied Studies--Radiation Effects--Radionuclide Effects--Internal Source--Man
LEUKOPENIA
N48610* --Life Sciences--Radionuclide Effects (Internal Source)--Man
PATIENTS
RADIATION DOSES
RADIOTHERAPY