THE EFFECTS OF X-IRRADIATION ON THE BIOSYNTHESIS OF HAEMOGLOBIN. III. EXPERIMENTS WITH PORPHOBILINOGEN-3,5-$sup 14$C

Journal Article · Sun Apr 01 04:00:00 EST 1962 · intern. J. Radiation Biol.

OSTI ID:4775171

Dancewicz, A M; Altman, K I; Salomon, K

The degree of incorporation of porphobilinogen-3,5-C/sup 14/ (PBG) into hemin was determined in bone-marrow homogenates of rabbits after 600 r, 800 r, or 1000 r of wholebody x irradiation. The time-periods studied after exposure to x rays ranged from 30 min to 48 days. In parallel with the capacity of bone-marrow to synthesize hemin, DNAconcentration and hemin-concentration were determined. The capacity of bone-marrow homogenate to synthesize hemin increased significantly on the first, seventh, and fourteenth day after exposure to 600 r and on the seventh and fourteenth day after exposure to 800 or 1000 r. After exposure to 800 r, similar patterns of radiation-induced changes were found when PBG or DAL were used as precursors. These patterns differed markedly from those observed when glycine was used as a precursor. (auth)

• Research Organization: Univ. of Rochester, N.Y.
• NSA Number: NSA-17-000061
• OSTI ID: 4775171
• Journal Information: intern. J. Radiation Biol., Journal Name: intern. J. Radiation Biol. Vol. Vol: 5
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINO ACIDS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BONE MARROW
CARBON 14
GLYCINE
HEMIN
HEMOGLOBIN
NUCLEIC ACIDS
PROTEINS
RADIATION DOSES
RADIATION EFFECTS
TRACER TECHNIQUES
X RADIATION