THE EFFECT OF X-IRRADIATION ON THE BIOSYNTHESIS OF HAEMOGLOBIN. II. EXPERIMENTS WITH /delta//-/ AMINOLEVULINIC ACID-2, 3-C$sup 1$$sup 4$

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Intern. J. Radiation Biol.

OSTI ID:4158050

Schulman, M; Altman, K I; Salomon, K

A new method for the synthesis of delta -aminolevulinic acid-2, 3-C/sup 14/ has been described. The incorporation of delta -aminolevulinic acid-2, 3-C/ sup 14/ into hemin was measured in bone-marrow homogenates from irradiated rabbits. At times between 0 and 28 days after 800 r of x radintion, the cellularity of the marrow, measured as its DNA-content, was found to have decreased. During the same period, the capacity of the homogenate to synthesize hemin from DAL also decreased. The changes observed could not be ascribed entirely to alterations in the cellularity of the marrow, and it is suggested that the synthesis of hemin per se is affecied by radiation. A comparison with a similar study with glycine-2-C/sub 14/ as a precursor of hemin hns revealed that the reactions bywhich DAL is formed from glycine and acetate are markedly inhibited on the seventh day after irradiation. (auth)

• Research Organization: Univ. of Rochester, N.Y.
• NSA Number: NSA-14-010356
• OSTI ID: 4158050
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 2
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACETATES
AMINO ACIDS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BONE MARROW
CARBON 14
DNA
GLYCINE
HEMIN
HEMOGLOBIN
LABELLED COMPOUNDS
MEASURED VALUES
METABOLISM
NUCLEIC ACIDS
RABBITS
RADIATION DOSES
RADIATION EFFECTS
TRACER TECHNIQUES
X RADIATION