Anaphylactic Hypersensitivity (Schultz-Dale Reaction) in Guinea-pigs Immunized with Autolyzed Spleen or Spleen from X-irradiated Rats

Journal Article · Sun Dec 31 23:00:00 EST 1961 · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine

DOI:https://doi.org/10.1080/09553006214550641· OSTI ID:4775169

Stanković, V.; Kečkeš, S.; Allegretti, N.

Guinea-pigs were injected with homogenized spleens of normal or irradiated rats (one day after 1000 r) or with autolyzed spleens of normal rats. Schultz-Dale reactions after different desensitizations in vitro with sensitizing materials were determined. The experimental data provide additional evidence for the existence of some new antigenic component(s) in irradiated spleen. This component is not radiation specific, for it is present in autolyzed spleen too, Some preliminary results are given, showing that previous immunization with such tissues renders the rats more susceptible to the lethal effect of irradiation.

• Research Organization: Institute 'Ruder Boskovic', Zagreb
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-000064
• OSTI ID: 4775169
• Journal Information: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 2 Vol. 5; ISSN 0020-7616
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANTIGENS
GUINEA PIGS
IMMUNITY
LIFETIME
RADIATION DOSES
RATS
SENSITIVITY
SPLEEN
TISSUES