Electro-shock Seizure Responses to Reserpine and Iproniazid after X-irradiation in Rats

Journal Article · Sun Jul 01 04:00:00 EDT 1962 · International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine

DOI:https://doi.org/10.1080/09553006214550821· OSTI ID:4775077

Rosenthal, Fred

Reserpine (2 mg/kg) and iproniazid (100 mg/kg) were administered to adult rats after single doses of 500 r whole-body x irradiation, Threshold for minimal electroshock seizures and pattern of maximal electro-shock seizures were studied under experimental conditions of drug injection and irradiation. X irradiation lowers threshold for minimal convulsions which suggests an increased brain excitability; it also shortens maximal tonic-- clonic convulsions, which in turn can be interpreted as a more rapid than normal onset of neutral fatigue. Reserpine has a synergistic effect on the post-irradiation fall in threshold while counteracting the shortening of the maximal seizure. Iproniazid has a less marked synergistic effect on the fall in threshold after irradiation and produces no significant change in the pattern of maximal convulsions. These results were interpreted in terms of a direct action of irradiation, reserpine, and iproniazid on brain function involving mechanisms related to brain serotonin. (auth)

• Research Organization: Univ. of California, Berkeley
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-000073
• OSTI ID: 4775077
• Journal Information: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 3 Vol. 5; ISSN 0020-7616
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALKALOIDS
AMINES
BIOLOGY AND MEDICINE
BODY
BRAIN
DISEASES
DRUGS
EPILEPSY
ISONIAZID
NERVOUS SYSTEM
PHYSIOLOGY
RADIATION DOSES
RATS
RESERPINE
SENSITIVITY
SEROTONIN
X RADIATION