THRESHOLD AND PATTERN OF ELECTROSHOCK SEIZURES AFTER 250 /cap gamma/ WHOLE- BODY X-IRRADIATION IN RATS

Journal Article · Sun Oct 01 04:00:00 EDT 1961 · Proc. Soc. Exptl. Biol. Med.

DOI:https://doi.org/10.3181/00379727-108-26911· OSTI ID:4836985

Rosenthal, F; Timiras, P S

The effects of single doses of 250 and 500 r whole-body irradiation on the threshold and pattern of electroshock seizures were followed in rats for 20 post-irradiation days. Irradiated rats had lower electroshock seizure thresholds than controls. Total duration of the maximal electroshock seizures was shorter in the irradiated rats than in the controls. This was due to a significant shortening of the clonic phase of the seizure. These findings are interpreted as indicating that brain excitability is increased by irradiation at 250 and 500 r. However, heightened seizure activity cannot be sustained as long in irradiated rats as in controls. The magnitude of the changes in brain convulsability was the same for the 2 doses of x irradiation while the effects on body growth were dosedependent in this range. (auth)

• Research Organization: Univ. of California, Berkeley
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-000075
• OSTI ID: 4836985
• Journal Information: Proc. Soc. Exptl. Biol. Med., Journal Name: Proc. Soc. Exptl. Biol. Med. Vol. Vol: 108
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BRAIN
ELECTROSHOCK
PHYSIOLOGY
RADIATION DOSES
RADIOSENSITIVITY
RATS
X RADIATION