THE EFFECTS OF COMPLEXONES ON THE BEHAVIOR OF METALS AND RADIACTIVE AGENTS IN THE BODY. III. Phosphates
Investigations were made to give the results of research carried out with complexones of the phosphate group to find the most effective and, at the same time, the least toxic complexones of the phosphate group and to determine the general pattern of their action on the behavior of radioactive agents in the body. The tests were carried out on white rats. Polyphosphates and metaphosphates (sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, sodium tetrametaphosphate, sodium trimetaphosphate, and sodium orthophosphate) were administered to the rats parenterally before, during, or soon after incorporation of radioactive agents (strontium, yttrium, lead, plutonium) in indicator quantities. The excretion of the radioactive agent with the urine and the stools was recorded and a dynamic study made of the radioactivity content of the liver, kidneys, skeleton, spleen, and carcass. It was found that administration of the poly- and metaphosphates led to a marked drop in deposition of the radioactive agent in the skeleton, increased its excretion with the urine, and intensified its deposition in the parenchymatous organs. The lower the dose of phosphate administered, the less the effect on the deposition of radioactive agent in the skeleton and excretion of the agent with the urine, but the more marked the increase in deposition of the radioactive agent in the soft organs. The lower the fraction of radioactive agent in the blood when the phosphate was injected, the less marked was the phosphate's effect on the agent's deposition in the organs and its excretion with the urine. In relation to most of the radioactive isotopes tested, phosphates proved less effective than EDTA. In contrast to the latter, however, they increased the excretion of radioactive strontium from the skeleton. It was concluded that trimetaphosphate, because of its low toxicity, lack of noticeable decomposition in the body and its ability to eluate radioactive strontium from the bone tissue, may have a possible clinical application. (OTS)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-16-032706
- OSTI ID:
- 4771543
- Journal Information:
- Trudy Inst. Biol., Akad. Nauk S.S.S.R., Ural'Filial, Journal Name: Trudy Inst. Biol., Akad. Nauk S.S.S.R., Ural'Filial Vol. Vol: 12
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
BLOOD
BONES
COMPLEXES
DECOMPOSITION
DISTRIBUTION
EDTA
EFFICIENCY
KIDNEYS
LEAD ISOTOPES
LIVER
MEDICINE
METABOLISM
PERFORMANCE
PHOSPHATES
PLUTONIUM ISOTOPES
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIOACTIVITY
RADIOISOTOPES
RATS
SODIUM PHOSPHATES
SPLEEN
STRONTIUM ISOTOPES
TESTING
TOXICITY
TRACER TECHNIQUES
URINE
YTTRIUM ISOTOPES