THE PROBLEM OF AUTOINFECTION AFTER TOTAL BODY LETHAL IRRADIATION OF DOGS WITH $sup 60$Co
Journal Article
·
· Folia Biologica (Prague) (Czechoslovakia)
OSTI ID:4771469
The role of autoinfection was studied as one of the causes of death in dogs exposed to lethal whole-body irradiation. Three-month-old puppies with an average weight of 3800 g were irradiated with a single whole-body dose of Co/sup 60/ totaling 750 r. The origin of autoinfection and time of infiltration of the bacteria into the blood and organs were studied. The time sequence of penetration of the bacteria from the intestine into the blood and organs was determined. Bacteria were demonstrated in the mesenteric lymph nodes on the second and fourth days after irradiation. In one case, they were also demonstrated in the liver. Between the fourth and severth days a relative decrease in the number of bacteria was observed. From the eighth day after irradiation, progressive mass invasion of the organs by bacteria of intestinal origin occurred. Between the eighth and tenth day after irradiation, bacteria were demonstrated in the mesenteric lymph node, spleen, liver, kidneys, and blood from the heart. By the twelfth day penetration progressed to such an extent that bacteria could be demonstrated in all the organs examined and also in blood from the heart. The average complement titre before irradiation was 1: 12 (1: 11.9). After irradiation a slight increase in complement was observed. A distinct increase in complement was found in three control animals which survived irradiation for more than ten days. In one control animal, which died on the tenth day, a mild decrease was recorded. In five experimental animals killed on the tenth and twelfth day after irradiation, a marked decrease was found. (auth)
- Research Organization:
- Safarik Univ., Kosice, Czechoslovakia
- NSA Number:
- NSA-17-004433
- OSTI ID:
- 4771469
- Journal Information:
- Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 8; ISSN FOBLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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