INFLUENCE OF CASTRATION AND OF TESTOSTERONE ON THE RADIOSENSITIVITY OF THE MUCOSA OF THE RABBIT JAW
The influence of these treatments on the local irradiation of rabbit jaw with 1000, 1500, 2000, 2500, and 3000 r was investigated. Changes in the surface area of nucleated cells, scraped from the mucosal surface 3 to 10 days after irradiation, were followed. Irradiation with the highest dose increased the cell surface area 4-fold in intact untreated rabbits. The increase was proportional to the radiation dose. Continuous daily treatment with testosterone enhanced this effect of irradiation -- 2-fold, whereas castration tended to inhibit the stimulatory effect of irradiation on cell surface area. These results confirm previous studies on rat vaginal mucosa and demonstrate that testosterone has a radiosensitizing action on mucosal cells. (H.H.D.)
- Research Organization:
- Universite, Liege
- NSA Number:
- NSA-16-032774
- OSTI ID:
- 4770865
- Journal Information:
- Compt. rend. soc. biol., Journal Name: Compt. rend. soc. biol. Vol. Vol: 156
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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