INACTIVATION OF BACTERIOPHAGE T6 IN AN AQUEOUS SYSTEM BY HIGH-ENERGY PROTONS

Technical Report · Sat Sep 01 04:00:00 EDT 1962

OSTI ID:4767403

Tanooka, H

The bacteriophage T8 was irradiated by high energy protons of different iinear energy transfer (LET) in order to study the effect of changing the LET in an aqueous system. The inactivation cross-section per proton remained constant for various LETs in a dilute system, resulting in a high inactivating efficiency of high energy protons per unit absorbed dose. Phages carrying the halogenated DNA were also studied in regard to the direct and the indirect inactivation by ionizing radiations. The increase of the radiosensitivity by the halogenation was found only on the direct action, suggesting the phage DNA is the principal target to the radiation. The substituted molecules themselves, 5bromodeoxyuridine and 5-iododeoxyuridine, were irradiated in an aqueous solution, showing the ring structure of the molecules is of the same degree of radiosensitivity as the normal component in DNA, thymidine, and not responsible for the increase of radiosensitivity. (auth)

• Research Organization: Rochester, N.Y. Univ. Atomic Energy Project
• NSA Number: NSA-17-002836
• OSTI ID: 4767403
• Report Number(s): UR-618
• Country of Publication: United States
• Language: English

Related Subjects

ABSORPTION
BACTERIOPHAGES
BIOLOGY AND MEDICINE
ENERGY LEVELS
HALOGENS
NUCLEIC ACIDS
PROTONS
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
THYMIDINE
WATER