Some aspects of the mechanism of bacteriophage function. Final progress report. [Mechanisms of inactivation of bacteriophages by ionizing radiation]
Data are summarized from a ten-year study on the radiobiology of phages. The results showed that: phages are inactivated principally by damage to DNA; DNA damage is of two types, base damage and double-strand breakage; double-strand breakage may be lethal because of interruption within a gene, however in phage systems the damage is more fundamental in that only a single DNA fragment is injected into the host; E. coli phage T4 is relatively resistant to inactivation by x-rays; and the rate of production of strand breaks and base damage is nearly the same in bacteriophage and bacteria.
- Research Organization:
- Brandeis Univ., Waltham, MA (USA). Graduate Dept. of Biochemistry
- OSTI ID:
- 7302853
- Report Number(s):
- COO-3233-6
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BACTERIOPHAGES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DNA
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
HOST-CELL REACTIVATION
INACTIVATION
IONIZING RADIATIONS
KINETICS
MICROORGANISMS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
REACTION KINETICS
RECOVERY
REPAIR
STRAND BREAKS
VIRUSES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BACTERIOPHAGES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DNA
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
HOST-CELL REACTIVATION
INACTIVATION
IONIZING RADIATIONS
KINETICS
MICROORGANISMS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
REACTION KINETICS
RECOVERY
REPAIR
STRAND BREAKS
VIRUSES
X RADIATION